Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers

Urinary Metabolomic Profiling after Administration of Corydalis Tuber and Pharbitis Seed Extract in Healthy Korean Volunteers

Blog Article

Pharmacometabolomics is a useful tool to identify biomarkers that can assess and predict response after drug administration.The primary purpose of pharmacometabolomics is to better understand the mechanisms and pathways of a drug by searching endogenous metabolites that have significantly changed after drug administration.DA-9701, a prokinetic agent, consists of Pharbitis seed and Corydalis tube extract and it is known to improve the gastrointestinal motility.

Although the overall mechanism of action ENERGIZER ACAIBERRY of DA-9701 remains unclear, its active ingredients, corydaline and chlorogenic Wooden Figure acid, act as a 5-HT3 and D2 receptor antagonist and 5-HT4 receptor agonist.To determine the significant metabolites after the administration of DA-9701, a qualitative analysis was carried out using ultra-high performance liquid chromatography coupled with orbitrap mass spectrometer followed by a multivariate analysis.Seven candidates were selected and a statistical analysis of fold change was performed over time.

Our study concluded that all the seven selected metabolites were commonly involved in lipid metabolism and purine metabolism.